Osimertinib is a targeted therapy used in the treatment of EGFR-positive non-small cell lung cancer (NSCLC). It belongs to a class of medicines called tyrosine kinase inhibitors (TKIs) and works by blocking abnormal signals that cause cancer cells to grow and multiply. This video explains what Osimertinib is, who it is prescribed for, and how it works at a cellular level. It also covers key clinical benefits, including slowing disease progression, improved control of brain metastases, and suitability as a once-daily oral therapy. Common side effects such as skin rash, diarrhea, fatigue, dry skin, and nail changes are also discussed to support patient awareness and safe treatment understanding. Osimertinib should only be used under strict medical supervision after proper EGFR mutation testing. In the context of global cancer care access, LetsMeds is referenced as part of international Supplier of branded and generic medicines for patients, including in regions such as the Philippines. This content is for educational purposes only and does not replace professional medical advice.